Corneal Neurotoxicity Due to Topical Benzalkonium Chloride
نویسندگان
چکیده
منابع مشابه
Corneal neurotoxicity due to topical benzalkonium chloride.
PURPOSE The aim of this study was to determine and characterize the effect of topical application of benzalkonium chloride (BAK) on corneal nerves in vivo and in vitro. METHODS Thy1-YFP+ neurofluorescent mouse eyes were treated topically with vehicle or BAK (0.01% or 0.1%). Wide-field stereofluorescence microscopy was performed to sequentially image the treated corneas in vivo every week for ...
متن کاملCorneal Alternations Induced by Topical Application of Benzalkonium Chloride in Rabbit
Benzalkonium chloride (BAC) is the most common preservative in ophthalmic preparations. Here, we investigated the corneal alternations in rabbits following exposure to BAC. Twenty-four adult male New Zealand albino rabbits were randomly divided into three groups. BAC at 0.01%, 0.05%, or 0.1% was applied twice daily to one eye each of rabbits for 4 days. The contralateral untreated eyes were use...
متن کاملBenzalkonium Chloride Suppresses Rabbit Corneal Endothelium Intercellular Gap Junction Communication
PURPOSE Gap junction intercellular communication (GJIC) plays a critical role in the maintenance of corneal endothelium homeostasis. We determined if benzalkonium chloride (BAK) alters GJIC activity in the rabbit corneal endothelium since it is commonly used as a drug preservative in ocular eyedrop preparations even though it can have cytotoxic effects. METHODS Thirty-six adult New Zealand al...
متن کاملEffects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs
To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.5%) and benzalkonium chloride 0.01%. Six healthy mixed breed dogs from the same litter were used in two diff...
متن کاملCorneal toxicity secondary to inadvertent use of benzalkonium chloride preserved viscoelastic material in cataract surgery.
AIMS To study the long term toxic effects of intraocular benzalkonium chloride (BAC). METHODS 19 patients exposed to intraocular BAC preserved viscoelastic during cataract surgery in February 1999 developed severe striate keratopathy immediately postoperatively. 16 patients, including two who underwent penetrating keratoplasty, were studied in the period April to June 2000. Ocular symptoms, v...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2012
ISSN: 1552-5783
DOI: 10.1167/iovs.11-8775